The start of the new series will see Donna tracking down the Time Lord during an alien emergency in modern-day London.
The couple are destined to experience a series of wonderful adventures throughout the new series including meeting one of Doctor Who's most popular aliens, The Ood, in a brand new episode, Planet Of The Ood.
Donna and The Doctor – David Tennant – will also be travelling through time for an encounter with the legendary murder mystery novelist, Agatha Christie.
Agatha Christie will be played by Jekyll star Fenella Woolgar and The Good Life actress Felicity Kendal will star as Lady Clemency Eddison.
Blackadder and Notting Hill actor Tim McInnerny will also guest star later in the series.
Doctor Who's executive producer and head writer, Russell T Davies comments: "Visiting Agatha Christie has been on my wish-list for ages now and, for the Doctor, it's a real meeting of minds! Viewers can expect many more ambitious storylines and a whole host of guest stars in 2008."
Mathew Prichard, Agatha Christie's grandson, comments: "What a brilliant idea that Agatha Christie and Doctor Who should meet! Two characters whose contribution to British entertainment is absolutely unrivalled.
"As far as I know my grandmother, Agatha Christie, never saw Doctor Who, but I am sure she would have been intrigued, excited and above all flattered by all this attention in 2007."
Catherine Tate said: "I am delighted to be returning to Doctor Who. I had a blast last Christmas and look forward to travelling again through time and space with that nice man from Gallifrey."
Freema Agyeman who has played Martha Jones, The Doctor's companion throughout the critically acclaimed third series, will return to the show to join The Doctor and Donna mid-series.
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"Layer Cake" director Matthew Vaughn is set to direct a big screen Thor movie.
Mark Protosevich (I Am Legend) is scripting the tale, which will bring the Norse god to life as he wields his mighty hammer Mjolnir and travels from his mystical home of Asgard to help the humans of Midgard.
The announcement comes just as Paramount releases Matthew's latest project Stardust, an adaptation of the Neil Gaiman novel, starring Robert De Niro and Michelle Pfeiffer.
It marks his second effort at a superhero pic. He was apparently attached to direct X-Men 3 before bowing out for personal reasons.
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Marvel Comics plans a direct-to-DVD animated Hulk movie.
"Hulk Smash"...is slated for release in October of 2008.
Huh. Wonder if the Doctor will have to solve a murder, only to discover Agatha was the culprit?
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